CBD In The Medical World

Cannabidiol

Cannabidiol (CBD) is a major component of the cannabis plant. More and more attention is being paid by researchers because it does not have psychoactive properties.

Chemical formula: C21H30O2

Molecular Weight: 314.46g / mol

Decarboxylation point: 115-145 ° C (239-293 ° F)

Boiling point: 180 ° C (356 ° F)

LD50 (lethal dose): 50 mg / kg in mice (Comparison with nicotine in mice - 3.34mg / kg, in humans - 40-60mg / kg)

 

CBD vs. THC

Cannabidiol (CBD) is one of the most common non-psychoactive cannabinoids in the cannabis plant, the highest concentration after THC. The reason for the psychoactive effect of THC is that it interacts with the CB1 receptor. However, CBD has no significant interaction with the CB1 receptor and instead uses a variety of other receptor sites. The special ability of CBD to reduce the psychoactive effect of THC is a strong anti-psychotic.

 

The beneficial effect of CBD

In addition to being non-psychoactive, CBD provides effective treatment for epileptic seizures, pain, inflammation, cancer, autoimmune diseases, and many other diseases. While THC is also an analgesic and anti-inflammatory, CBD has been shown to be more effective than THC and traditional pharmacy drugs. In research, CBD showed outstanding antioxidant effects, according to studies 30, 50% stronger than vitamin E and vitamin C. \ t Japanese researchers have shown that the antioxidant effect of CBD is stronger than THC. THC and CBD also have analgesic effects in users, but they have a completely different mechanism of action. THC helps the patient forget or tolerate pain to distract its attention. CBD reduces the amount of sensed pain at injury, which is more similar to that of conventional opiate analgesics.

Given its non-psychoactive and wide-ranging medical applications, CBD is highly recommended for the treatment of children, the elderly, and patients who want to stay clean while taking advantage of the cannabis healing properties. It seems that CBD changes the way THC works in the body, makes it less psychoactive, but also strengthens its therapeutic effects. Many people, who are new to take cannabis foods, report excessive dizziness and negative experiences after the first time. When this happens, CBD-rich tincture can reduce the psychoactive effects of THC, and help to feel well.

 

Legal or illegal

Widespread medical applications, coupled with a lack of psychoactive effects, have encouraged more than a dozen US states to introduce only CBD medical cannabis laws, thereby legalizing part of the plant while keeping the other part illegally. In fact, patients are badly served because even those who need CBD treatment often need THC, THCA or CBG. Children with epilepsy use a very high THC: CBD ratio, up to 1:28, but sometimes they need THC and seem to provide additional help to THCA and CBG. It has been shown that the combination of different cannabinoids has a stronger effect than any cannabinoid alone, this effect, the so-called Combination Effect. Many companies are trying to get money fast in the CBD Green Fever and many low-quality products come up on the market, with an unrealistically high price. ProjectCBD called these Snake Oil Dealers "Hemp Oil Cheaters". The problem is so great that in February 2015, the FDA sent a warning letter to a number of companies and told them that CBD product tests did not show as high values as they claimed and were not approved by the FDA.

 

At moderate doses, CBD causes mild alertness. Cannabidiol activates the same adenosine receptors as caffeine, which is a stimulant. But some studies, as well as several patients with sleep problems, reported that the consumption of CBD-rich tincture or extract a few hours before bedtime had a balancing effect that promotes good sleep. In clinical trials of patients with chronic pain on Sativex, it has been observed that they significantly improve sleep. This formulation contains THC and CBD in equal proportions, suggesting that the two compounds work together to produce this beneficial effect.

 

Recent studies

Sleep: CBD is considered a sedative, mistakenly. At moderate doses, CBD causes mild alertness. Cannabidiol activates the same adenosine receptors as caffeine, which is a stimulant. But some studies, as well as several patients with sleep problems, reported that the consumption of CBD-rich tincture or extract a few hours before bedtime had a balancing effect that promotes good sleep. In clinical trials of patients with chronic pain on Sativex, it has been observed that they significantly improve sleep. This formulation contains THC and CBD in equal proportions, suggesting that the two compounds work together to produce this beneficial effect.

 

Alzheimer's Disease / Dementia / Memory Loss: The strong neuroprotective and antioxidant effect of CBD together counteracts aging of our brain, fighting memory dysfunction and dementia. In research, CBD reversed the brain deficit caused by Alzheimer's.

 

Bone Healing: A 2015 study shows that CBD's ability to stimulate bone growth is strong enough to speed up and heal broken bones. The same study found that THC has a linked role in the treatment of broken bones in collaboration with the CBD.

 

Cancer: A study published in 2007 reported that ongoing research is taking place at the San Francisco-California Pacific Medical Center, which shows that CBD inhibits a particular gene (Id-1) responsible for the growth of cancer cells in the body. By blocking this gene, CBD stops the growth of cancer cells, potentially stopping or even reversing tumor growth.

More and more research has focused on the antitumor effects of CBD on various types of cancer, which have proven their THC-like abilities, including anti-proliferative, anti-invasive, blood vessel-forming and metastatic-inhibiting, and THC-induced apoptosis, ie programmed cell death. Among the important researches, those synergistic, so-called 'social effects' of THC and CBD combined have been highlighted. In addition to research in the lab (test tube, pre-tissues and animal models), there are clinical studies that can finally give a clear answer to many of the most important questions: Can Cannabinoids cure cancer?

 

Dravet Syndrome / Epilepsy: In 2013, the results of a clinical study to measure the therapeutic use of CBD in untreated epileptic children were started and arrived in 2016. The CBD formulation (Epidiolex®) is manufactured by a British pharmaceutical company, GW Pharmaceuticals, the maker of Sativex. Dravet is a rare disorder, usually, the first untreatable seizure occurs before the age of one year and in exceptional cases, seizures can last up to 24 hours. Charlotte Figgi was one of the first Dravet syndromes whose parents successfully treated with CBD-rich cannabis oil.

 

Depression / Anxiety: CBD stimulates the 5-HT1A receptor in the brain, the region involved in serotonin reuptake and other processes that support depression and anxiety. The antidepressant properties of CBD are very similar to the tricyclic antidepressant, imipramine (which is also being tested for panic disorder).

 

Diabetes: The CBD was first discovered in 2006 to diminish the effects of diabetes. It has since been shown that it has many benefits for diabetics, especially in reducing neurotoxicity and inflammation. In a follow-up study in 2010, CBD was found to provide protection against neurodegeneration. According to another study in 2010, CBD has high therapeutic potential for the treatment of diabetes complications and possibly in other cardiovascular disorders.

 

Inflammatory bowel disease / Crohn's disease: CBD is very promising in the control of inflammatory responses and malaise caused by Crohn's disease and IBD. CBD has the potential to control these diseases, being currently being considered as a new class of IBD drugs.

 

Nausea: In a study of nausea and vomiting, CBD has been shown to have anti-emetic and anti-nausea effects. The same study found that CBG can block these nausea effects, perhaps because moderate doses of CBD and CBG may conflict with each other at the 5HTP1a receptor in the brain.

 

Schizophrenia / Psychosis: CBD is a powerful antipsychotic and currently used in the treatment of schizophrenia and other psychoses, in several clinical trials. Cannabidiol appears to have a very similar chemical profile to some atypical antipsychotic drugs.

Alex Mihailov